Correction: The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells

نویسندگان

  • Alejo Chorny
  • Sandra Casas-Recasens
  • Jordi Sintes
  • Meimei Shan
  • Nadia Polentarutti
  • Ramón García-Escudero
  • A. Cooper Walland
  • John R. Yeiser
  • Linda Cassis
  • Jorge Carrillo
  • Irene Puga
  • Cristina Cunha
  • Hélder Bastos
  • Fernando Rodrigues
  • João F. Lacerda
  • António Morais
  • Rebeca Dieguez-Gonzalez
  • Peter S. Heeger
  • Giovanni Salvatori
  • Agostinho Carvalho
  • Adolfo Garcia-Sastre
  • J. Magarian Blander
  • Alberto Mantovani
  • Cecilia Garlanda
  • Andrea Cerutti
چکیده

Alejo Chorny, Sandra Casas-Recasens, Jordi Sintes, Meimei Shan, Nadia Polentarutti, Ramón García-Escudero, A. Cooper Walland, John R. Yeiser, Linda Cassis, Jorge Carrillo, Irene Puga, Cristina Cunha, Hélder Bastos, Fernando Rodrigues, João F. Lacerda, António Morais, Rebeca Dieguez-Gonzalez, Peter S. Heeger, Giovanni Salvatori, Agostinho Carvalho, Adolfo Garcia-Sastre, J. Magarian Blander, Alberto Mantovani, Cecilia Garlanda, and Andrea Cerutti

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The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells

Pentraxin 3 (PTX3) is a fluid-phase pattern recognition receptor of the humoral innate immune system with ancestral antibody-like properties but unknown antibody-inducing function. In this study, we found binding of PTX3 to splenic marginal zone (MZ) B cells, an innate-like subset of antibody-producing lymphocytes strategically positioned at the interface between the circulation and the adaptiv...

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Pathogen Recognition by the Long Pentraxin PTX3

Innate immunity represents the first line of defence against pathogens and plays key roles in activation and orientation of the adaptive immune response. The innate immune system comprises both a cellular and a humoral arm. Components of the humoral arm include soluble pattern recognition molecules (PRMs) that recognise pathogen-associated molecular patterns (PAMPs) and initiate the immune resp...

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The “sweet” side of a long pentraxin: how glycosylation affects PTX3 functions in innate immunity and inflammation

Innate immunity represents the first line of defense against pathogens and plays key roles in activation and orientation of the adaptive immune response. The innate immune system comprises both a cellular and a humoral arm. Components of the humoral arm include soluble pattern recognition molecules (PRMs) that recognize pathogen-associated molecular patterns and initiate the immune response in ...

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Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors.

Outer membrane protein A (OmpA) is a conserved major component of the outer membrane of Enterobacteriaceae. Here, we report that OmpA from Klebsiella pneumoniae (KpOmpA) activates macrophages and dendritic cells (DCs) in a TLR2-dependent way. However, TLR2 does not account for binding of KpOmpA to innate immune cells. KpOmpA binds the scavenger receptors (SRs) LOX-1 and SREC-I, but not other me...

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Pentraxin 3: An Immuno-Regulator in the Lungs

Pentraxin 3 (PTX3) is a soluble pattern recognition receptor that is a humoral component of the innate immune system. It interacts with pathogenic moieties, infected and dying host cells and facilitates their removal through activation of appropriate innate and adaptive mechanisms. PTX3 is secreted by a diverse variety of cells, ranging from immune cells to structural cells, in response to Toll...

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عنوان ژورنال:

دوره 214  شماره 

صفحات  -

تاریخ انتشار 2017